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B-Raf 抑制剂

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产品目录号: A10829


产品名 目录号 价格 数量
SB590885 5mg A10829-5
¥ 900.00
SB590885 10mg A10829-10
¥ 1,360.00
SB590885 50mg A10829-50
¥ 4,500.00
SB590885 100mg A10829-100
¥ 7,500.00



SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10829
Mechanism of action Inhibitor
分子量 453.5
化学分子式 C27H27N5O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 405554-55-4
Synonyms SB-590885
SMILES code CN(C)CCOC1=CC=C(C=C1)C2=N/C(=C\3/C=CC4=C(CCC4=C3)N=O)/C(=C5C=CNC=C5)N2
化学名称 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime


SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.
B-Raf (Cell-free assay)
0.16 nM(Ki)


Solubility (25°C) * In vitro DMSO 5 mg/mL (11.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.05 mL 110.25 mL 220.51mL
0.5 mM 4.41 mL 22.05 mL 44.1 mL
1 mM 2.21 mL 11.03 mL 22.05 mL
5 mM 0.44 mL 2.21 mL 4.41 mL

*The above data is based on the productmolecular weight 453.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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