SB939 ( Pracinostat )

目录号: A10830

HDAC 抑制剂

SB939 ( Pracinostat )

SB939 ( Pracinostat ) Chemical Structure

CAS NO. 929016-96-6

SB939 (Pracinostat)是HDAC的口服抑制剂,对I,II和IV类HDAC具有选择性,在体外HDAC1活性测定中显示IC50值为77 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,300.00
50 mg
¥ 4,000.00
100 mg
¥ 7,200.00
10mM * 1mL in DMSO
¥ 1,240.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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SB939 (Pracinostat)是HDAC的口服抑制剂,对I,II和IV类HDAC具有选择性,在体外HDAC1活性测定中显示IC50值为77 nM。
Targets
Target Value
HDAC10IC50: 40nM
HDAC3IC50: 43nM
HDAC5IC50: 47nM
HDAC1IC50: 49nM
HDAC4IC50: 56nM
HDAC9IC50: 70nM
HDAC11IC50: 93nM
HDAC2IC50: 96nM
HDAC7IC50: 137nM
HDAC8IC50: 140nM
HDAC6IC50: 1.008μM
SIRT1IC50: >100μM
In vitro (25°C) DMSO 72 mg/mL (200.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol 27 mg/mL (75.31 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.89 mL 139.47 mL 278.94 mL
0.5 mM 5.58 mL 27.89 mL 55.79 mL
1 mM 2.79 mL 13.95 mL 27.89 mL
5 mM 0.56 mL 2.79 mL 5.58 mL

*The above data is based on the productmolecular weight 358.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10830
作用机制 Inhibitor (抑制剂)
M. Wt 358.5
Formula C20H30N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 929016-96-6
Synonyms Pracinostat, SB-939
SMILES CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)/C=C/C(=O)NO

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