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SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.16 mL | 115.79 mL | 231.59 mL |
| 0.5 mM | 4.63 mL | 23.16 mL | 46.32 mL |
| 1 mM | 2.32 mL | 11.58 mL | 23.16 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
*The above data is based on the productmolecular weight 431.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22295 |
|---|---|
| M. Wt | 431.8 |
| Formula | C21H13ClF3N3O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 1400989-25-4 |
| SMILES | O=C(NC1=CC=CC(OC2=CC=C(C#N)C=C2)=C1)NC3=CC=C(Cl)C(C(F)(F)F)=C3 |
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