产品详情

生物活性

SC-514是一种具有口服活性的，具有ATP竞争性的IKKβ抑制剂（IC50 = 3-12μM），其选择性是JNK，p38，MK2和ERK等28种其他激酶的10倍以上。

Targets

Target	Value
IKK2	IC50: 3μM-12μM
CDK2/CyclinA	IC50: 61μM
AUR2	IC50: 71μM
PRAK	IC50: 75μM
p38α	IC50: >100μM
p38β	IC50: >100μM
p38γ	IC50: >100μM
p38δ	IC50: >100μM
ERK2	IC50: >100μM
GSK-3	IC50: >100μM
NIM1	IC50: >100μM
Chk1	IC50: >100μM
PAK5	IC50: >100μM
PKA	IC50: >100μM
PKCβ	IC50: >100μM
Lyn	IC50: >100μM
FGFR1	IC50: >100μM
EGFR	IC50: >100μM
LCK	IC50: >100μM
c-Abl	IC50: >100μM
MSK	IC50: 123μM
JNK1	IC50: >200μM
JNK2	IC50: >200μM
JNK3	IC50: >200μM
MK2	IC50: >200μM
MK3	IC50: >200μM
RSKB	IC50: >200μM
MKK7	IC50: >200μM

溶解度 *

In vitro (25°C)	DMSO	41 mg/mL (182.79 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	44.58 mL	222.92 mL	445.83 mL
0.5 mM	8.92 mL	44.58 mL	89.17 mL
1 mM	4.46 mL	22.29 mL	44.58 mL
5 mM	0.89 mL	4.46 mL	8.92 mL

*The above data is based on the productmolecular weight 224.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12746
作用机制	Inhibitor (抑制剂)
M. Wt	224.3
Formula	C9H8N2OS2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	354812-17-2
Synonyms	SC514, SC 514
SMILES	C1=CSC=C1C2=CC(=C(S2)C(=O)N)N