SCH 442416
目录号: A12695
A2A Receptor Ant激动剂
SCH 442416 是一种选择性的腺苷 A2A 受体拮抗剂；它与人类和大鼠的 A2A 受体 具有高亲和力（Ki 值分别为 0.048 和 0.5 nM）。在体外对 hA2A 比 hA1 的选择性超过 23000 倍，对 hA2B 和 hA3 受体的亲和力极低（IC50 > 10 μM）。
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生物活性
| Discription | SCH 442416 is a selective adenosine A2A receptor antagonist; binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA2A over hA1 in vitro with minimal affinity for hA2B and hA3 receptors (IC50 > 10 μM). |
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产品信息
| 目录号 | A12695 |
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| 分子式 | C20H19N7O2 |
| 分子量 | 389.42 |
| CAS号 | 316173-57-6 |
| SMILES | COC1=CC=C(C=C1)CCCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5 |
| 其他名称 | SCH442416, SCH-442416 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 72 mg/mL (184.89 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.68 mL | 128.4 mL | 256.79 mL |
| 0.5 mM | 5.14 mL | 25.68 mL | 51.36 mL |
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 316173-57-6 | 316173-57-6 供应商 | 316173-57-6 花费 | 316173-57-6 生产商 | 订购 316173-57-6 | 316173-57-6 代理商