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SCH 900776 (MK-8776)

促销

Chk1 抑制剂

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产品目录号: A11167

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SCH 900776 5mg A11167-5
¥ 900.00
SCH 900776 10mg A11167-10
¥ 1,600.00
SCH 900776 50mg A11167-50
¥ 4,500.00
SCH 900776 100mg A11167-100
¥ 7,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

SCH 900776 (MK-8776)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 SCH 900776 (MK-8776) 发表的文献 (2)
  • Permata TBM, .et al. Base excision repair regulates PD-L1 expression in cancer cells, Oncogene, 2019, Feb 12 PMID: 30755733
  • Hiro Sato, .et al. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells, Nat Commun, 2017, 8: 1751 PMID: 29170499

Chemical Information

目录号 A11167
Mechanism of action Inhibitor
分子量 376.25
化学分子式 C15H18BrN7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 891494-63-6
Synonyms SCH-900776, MK-8776, MK8776, MK 8776
SMILES code CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)[C@H]4CCCNC4
化学名称 (R)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine

生物活性

Description

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

溶解性

Solubility (25°C) * In vitro DMSO 3 mg/mL (7.97 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 4% DMSO/30% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.58 mL 132.89 mL 265.78mL
0.5 mM 5.32 mL 26.58 mL 53.16 mL
1 mM 2.66 mL 13.29 mL 26.58 mL
5 mM 0.53 mL 2.66 mL 5.32 mL

*The above data is based on the productmolecular weight 376.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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