Selitrectinib

Name: Selitrectinib
SKU: A19252
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A19252

TKI 抑制剂

Selitrectinib（LOXO-195）是一种新一代的TRK激酶抑制剂（TKI），其IC50分别为0.6 nM和小于2.5 nM，针对TRKA和TRKC。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
5mg	¥525.00	现货
10mg	¥805.00	现货
25mg	¥1,610.00	现货
50mg	¥2,450.00	现货
100mg	¥3,255.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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Data Sheet

SDS

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生物活性

Discription

Selitrectinib (LOXO-195) is a next-generation TRK kinase inhibitor (TKI), with IC50s of 0.6 nM, <2.5 nM for TRKA and TRKC respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A19252
分子式	C20H21FN6O
分子量	380.42
CAS号	2097002-61-2
SMILES	FC1=CN=C(CC[C@H](N2)C)C([C@](CCC3)([H])N3C(C=CN4N=C5)=NC4=C5C2=O)=C1
其他名称	LOXO-195, LOXO 195, LOXO 195
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	35 mg/mL (91.99 mM)
	Water	Insoluble
	Ethanol	14 mg/mL (36.8 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.43 mL	262.87 mL
0.5 mM	5.26 mL	26.29 mL	52.57 mL
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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