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Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker with IC50 value of 11 nM. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.93 mL | 154.64 mL | 309.27 mL |
| 0.5 mM | 6.19 mL | 30.93 mL | 61.85 mL |
| 1 mM | 3.09 mL | 15.46 mL | 30.93 mL |
| 5 mM | 0.62 mL | 3.09 mL | 6.19 mL |
*The above data is based on the productmolecular weight 323.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11568 |
|---|---|
| 作用机制 | Blocker (阻断剂) |
| M. Wt | 323.34 |
| Formula | C20H15F2NO |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 289656-45-7 |
| Synonyms | ICA 17043, ICA17043 |
| SMILES | O=C(C(C1=CC=CC=C1)(C2=CC=C(C=C2)F)C3=CC=C(F)C=C3)N |
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