Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody designed to specifically target HER3. This antibody effectively inhibits the activation of members of the epidermal growth factor receptor (ErbB) family and their downstream signaling pathways. Seribantumab has demonstrated the ability to suppress neuregulin 1 (NRG1) fusion-dependent tumorigenesis both in vitro and in vivo, showing efficacy in patient-derived models of breast, lung, and ovarian cancers. This makes it a valuable tool for research in cancer biology, particularly in studies focusing on the molecular mechanisms of tumorigenesis and therapeutic antibody development.
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody designed to specifically target HER3. This antibody effectively inhibits the activation of members of the epidermal growth factor receptor (ErbB) family and their downstream signaling pathways. Seribantumab has demonstrated the ability to suppress neuregulin 1 (NRG1) fusion-dependent tumorigenesis both in vitro and in vivo, showing efficacy in patient-derived models of breast, lung, and ovarian cancers. This makes it a valuable tool for research in cancer biology, particularly in studies focusing on the molecular mechanisms of tumorigenesis and therapeutic antibody development.
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