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Setmelanotide (RM-493; BIM-22493; IRC-022493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 8.95 mL | 44.75 mL | 89.5 mL |
| 0.5 mM | 1.79 mL | 8.95 mL | 17.9 mL |
| 1 mM | 0.9 mL | 4.48 mL | 8.95 mL |
| 5 mM | 0.18 mL | 0.9 mL | 1.79 mL |
*The above data is based on the productmolecular weight 1117.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20689 |
|---|---|
| M. Wt | 1117.31 |
| Formula | C49H68N18O9S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 920014-72-8 |
| Synonyms | RM-493, RM493, RM 493; BIM-22493, BIM22493, BIM 22493; IRC-022493, IRC022493, IRC 022493 |
| SMILES | O=C(N[C@@H](CSSC[C@](C(N[C@@H]1C)=O)([H])NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(N)=O)[C@@H](NC([C@@H](NC([C@@](NC([C@@H](NC1=O)CC2=CN=CN2)=O)([H])CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45 |
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