SF1670
目录号: A13475
PTEN 抑制剂
SF1670 是一种选择性的 PTEN 抑制剂（IC50=2 uM）。由于 PTEN-mTOR 通路 对控制脊髓神经元的再生能力至关重要，PTEN 的删除或其抑制剂可以增强成年脊髓神经元的再生能力。在临床相关的小鼠模型中，预处理 SF1670 可以增强粒细胞输注的效果。
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生物活性
| Discription | SF1670 is a selective PTEN inhibitor (IC50=2 uM). As PTEN-mTOR pathway is critical for controlling the regenerative capacity of corticospinal neurons, PTEN deletion or its inhibitor enhances the regenerative ability of adult corticospinal neurons. Pretreatment with SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. | ||
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产品信息
| 目录号 | A13475 |
|---|---|
| 分子式 | C19H17NO3 |
| 分子量 | 307.4 |
| CAS号 | 345630-40-2 |
| SMILES | CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O |
| 其他名称 | SF 1670, SF-1670 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | Warmed: 27 mg/mL (87.84 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 1 mg/mL (3.25 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.53 mL | 162.65 mL | 325.31 mL |
| 0.5 mM | 6.51 mL | 32.53 mL | 65.06 mL |
| 1 mM | 3.25 mL | 16.27 mL | 32.53 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 345630-40-2 | 345630-40-2 供应商 | 345630-40-2 花费 | 345630-40-2 生产商 | 订购 345630-40-2 | 345630-40-2 代理商