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SGC 0946


DOT1L 抑制剂

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产品目录号: A12941


产品名 目录号 价格 数量
SGC 0946 5mg A12941-5
¥ 600.00
SGC 0946 10mg A12941-10
¥ 1,000.00
SGC 0946 25mg A12941-25
¥ 2,000.00
SGC 0946 50mg A12941-50
¥ 3,500.00



SGC 0946 is a potent DOT1L methyltransferase inhibitor that blocks H3K79 methylation in A431 cells and MCF10A cells.

SGC 0946




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Chemical Information

目录号 A12941
Mechanism of action Inhibitor
分子量 618.57
化学分子式 C28H40BrN7O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
Synonyms SGC0946, SGC-0946
SMILES code CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C(=CC4=C3N=CN=C4N)Br)O)O
化学名称 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea


SGC 0946 is a potent DOT1L methyltransferase inhibitor that blocks H3K79 methylation in A431 cells and MCF10A cells.
DOT1L (Cell-free assay)
0.3 nM


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.17 mL 80.83 mL 161.66mL
0.5 mM 3.23 mL 16.17 mL 32.33 mL
1 mM 1.62 mL 8.08 mL 16.17 mL
5 mM 0.32 mL 1.62 mL 3.23 mL

*The above data is based on the productmolecular weight 618.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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