SGC 0946
目录号: A12941
DOT1L 抑制剂
SGC 0946 是一种强效的 DOT1L methyltransferase 抑制剂，能够阻断 A431 细胞和 MCF10A 细胞中的 H3K79 methylation。
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生物活性
| Discription | SGC 0946 is a potent DOT1L methyltransferase inhibitor that blocks H3K79 methylation in A431 cells and MCF10A cells. | ||
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| Targets |
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产品信息
| 目录号 | A12941 |
|---|---|
| 分子式 | C28H40BrN7O4 |
| 分子量 | 618.57 |
| CAS号 | 1561178-17-3 |
| SMILES | CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C(=CC4=C3N=CN=C4N)Br)O)O |
| 其他名称 | SGC0946, SGC-0946 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 98 mg/mL (158.43 mM) | |
| Water | Insoluble | ||
| Ethanol | 98 mg/mL (158.43 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.17 mL | 80.83 mL | 161.66 mL |
| 0.5 mM | 3.23 mL | 16.17 mL | 32.33 mL |
| 1 mM | 1.62 mL | 8.08 mL | 16.17 mL |
| 5 mM | 0.32 mL | 1.62 mL | 3.23 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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