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SGI 1027


DNMT 抑制剂

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产品目录号: A14120


产品名 目录号 价格 数量
SGI 1027 10mg A14120-10
¥ 900.00
SGI 1027 25mg A14120-25
¥ 1,800.00
SGI 1027 50mg A14120-50
¥ 3,100.00
SGI 1027 10mM * 1mL in DMSO A14120-10mM-D
¥ 1,100.00



SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.

SGI 1027




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Chemical Information

目录号 A14120
Mechanism of action Inhibitor
分子量 461.52
化学分子式 C27H23N7O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1020149-73-8
Synonyms SGI-1027, SGI1027
SMILES code CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
化学名称 N-(4-((2-amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide


SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.
DNMT1 (Cell-free assay) DNMT3B (Cell-free assay) DNMT3A (Cell-free assay)
6 μM7.5 μM8 μM


Solubility (25°C)* In vitro DMSO 92 mg/mL (199.34 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.67 mL 108.34 mL 216.68mL
0.5 mM 4.33 mL 21.67 mL 43.34 mL
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL

*The above data is based on the productmolecular weight 461.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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