SGI-1776 (free base)

Name: SGI-1776 (free base)
SKU: A10838
Price: 280 CNY
Rating: 5 (1 reviews)

目录号: A10838

PIM1 抑制剂

1 篇发表文献

SGI-1776 free base 是一种新型的 ATP 竞争性抑制剂，针对 Pim1，其在无细胞测定中的 IC50 为 7 nM，相对于 Pim2 和 Pim3 分别具有 50 倍和 10 倍的选择性，同时对 Flt3 和 haspin 也具有强效。目前处于第一阶段临床试验。

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Grouped product items
规格	价格	库存
2mg	¥280.00	现货
5mg	¥560.00	现货
10mg	¥1,015.00	现货
25mg	¥1,925.00	现货
50mg	¥2,835.00	现货
100mg	¥4,095.00	现货
*10mM 1mL in DMSO**	¥630.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用SGI-1776 (free base)发表的1篇文献

Ishikawa C, .et al. , Eur J Haematol, 2017, Dec;99(6):495-504 PMID: 28833639

生物活性

Discription

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10838
分子式	C20H22F3N5O
分子量	405.4
CAS号	1025065-69-3
SMILES	CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
其他名称	SGI1776
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	70 mg/mL (172.66 mM)
	Water	Insoluble
	Ethanol	70 mg/mL (172.66 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.67 mL	123.33 mL	246.67 mL
0.5 mM	4.93 mL	24.67 mL	49.33 mL
1 mM	2.47 mL	12.33 mL	24.67 mL
5 mM	0.49 mL	2.47 mL	4.93 mL

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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