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SGI-1776 (free base)

促销

PIM1 抑制剂

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产品目录号: A10838

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SGI-1776 5mg A10838-5
¥ 850.00
SGI-1776 10mg A10838-10
¥ 1,500.00
SGI-1776 25mg A10838-25
¥ 2,800.00
SGI-1776 50mg A10838-50
¥ 4,100.00
SGI-1776 (free base) 10mM * 1mL in DMSO A10838-10mM-D
¥ 950.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

SGI-1776 (free base)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 SGI-1776 (free base) 发表的文献 (1)
  • Ishikawa C, .et al. Expression and significance of Pim-3 kinase in adult T-cell leukemia, Eur J Haematol, 2017, Dec;99(6):495-504 PMID: 28833639

Chemical Information

目录号 A10838
Mechanism of action Inhibitor
分子量 405.4
化学分子式 C20H22F3N5O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1025065-69-3
Synonyms SGI1776
SMILES code CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
化学名称 N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine sulfate

生物活性

Description
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

溶解性

Solubility (25°C) * In vitro DMSO 81 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 81 mg/mL (199.79 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.67 mL 123.33 mL 246.67mL
0.5 mM 4.93 mL 24.67 mL 49.33 mL
1 mM 2.47 mL 12.33 mL 24.67 mL
5 mM 0.49 mL 2.47 mL 4.93 mL

*The above data is based on the productmolecular weight 405.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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