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SGI-7079

Axl 抑制剂

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产品目录号: A15864

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SGI-7079 5mg A15864-5
¥ 800.00
SGI-7079 10mg A15864-10
¥ 1,400.00
SGI-7079 25mg A15864-25
¥ 2,800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SGI-7079 ,a novel selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.

SGI-7079

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Chemical Information

目录号 A15864
Mechanism of action Inhibitor
分子量 455.53
化学分子式 C26H26FN7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1239875-86-5
Synonyms SGI7079, SGI 7079
SMILES code N#CCC1=CC=CC(C2=C3C(NC=C3C)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1
化学名称 Benzeneacetonitrile, 3-?[2-?[[3-?fluoro-?4-?(4-?methyl-?1-?piperazinyl)?phenyl]?amino]?-?5-?methyl-?7H-?pyrrolo[2,?3-?d]?pyrimidin-?4-?yl]?-

生物活性

Description
SGI-7079 ,a novel selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.
Targets
Target Value
Met
Mer
YES
RET
FLT3
AxlIC50: 58nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.95 mL 109.76 mL 219.52mL
0.5 mM 4.39 mL 21.95 mL 43.9 mL
1 mM 2.2 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.2 mL 4.39 mL

*The above data is based on the productmolecular weight 455.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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