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SGX-523

促销

c-Met 抑制剂

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产品目录号: A10839

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SGX-523 5mg A10839-5
¥ 400.00
SGX-523 10mg A10839-10
¥ 600.00
SGX-523 50mg A10839-50
¥ 1,800.00
SGX-523 100mg A10839-100
¥ 3,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.

SGX-523

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Chemical Information

目录号 A10839
Mechanism of action Inhibitor
分子量 359.4
化学分子式 C18H13N7S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1022150-57-7
Synonyms SGX523
SMILES code CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2
化学名称 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline

生物活性

Description
SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.
Targets
Target Value
c-MetIC50: 4nM
B-Raf(V599E)IC50: >7μM
C-RafIC50: >7μM
AblIC50: >7μM
p38αIC50: >7μM
Abl1(Y253F)IC50: >7μM

溶解性

Solubility (25°C) * In vitro DMSO 2 mg/mL (5.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.82 mL 139.12 mL 278.24mL
0.5 mM 5.56 mL 27.82 mL 55.65 mL
1 mM 2.78 mL 13.91 mL 27.82 mL
5 mM 0.56 mL 2.78 mL 5.56 mL

*The above data is based on the productmolecular weight 359.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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