Siamycin I（BMY-29304），一种21残基的三环肽，是放线菌中的一种次级代谢产物。Siamycin I 是一种 HIV 融合抑制剂，对急性 HIV 类型 1（HIV-1）和 HIV-2 感染的 ED50 为 0.05 至 5.7 μM。Siamycin I 通过 FsrC-FsrA 双组分调控系统以非竞争性方式抑制明胶酶和明胶酶生物合成激活信息素（GBAP）信号。Siamycin I 抑制 fsrBDC 和 gelE-sprE 转录的表达。Siamycin I，一种 套索肽，与脂质 II 相互作用并抑制细胞壁生物合成。Siamycin I 作为一种抗生素，具有研究肠球菌感染的潜力。
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research.
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