Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody designed to inhibit the activity of a proliferation-inducing ligand (APRIL). This antibody selectively suppresses pathogenic immunoglobulins, specifically IgA and IgM, while maintaining effective antibody responses to mRNA-based SARS-CoV-2 vaccines. Additionally, Sibeprenlimab has demonstrated potential in reducing the urinary protein-to-creatinine ratio (UPCR) and stabilizing glomerular filtration rate (GFR), indicating its utility in the investigation of IgA nephropathy (IgAN). This makes Sibeprenlimab a valuable tool for research focused on autoimmune renal disorders and immune response modulation.
Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody designed to inhibit the activity of a proliferation-inducing ligand (APRIL). This antibody selectively suppresses pathogenic immunoglobulins, specifically IgA and IgM, while maintaining effective antibody responses to mRNA-based SARS-CoV-2 vaccines. Additionally, Sibeprenlimab has demonstrated potential in reducing the urinary protein-to-creatinine ratio (UPCR) and stabilizing glomerular filtration rate (GFR), indicating its utility in the investigation of IgA nephropathy (IgAN). This makes Sibeprenlimab a valuable tool for research focused on autoimmune renal disorders and immune response modulation.
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