Sitagliptin phosphate monohydrate

目录号: A10848

DDP-4 inhibitor

Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate Chemical Structure

CAS NO. 654671-77-9

Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.

库存: 现货

规格 价格 数量
200 mg
¥ 600.00
500 mg
¥ 1,000.00
10mM * 1mL in DMSO
¥ 610.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.
Targets
DPP-4 (Cell-free assay)
19 nM
In vitro (25°C) DMSO 100 mg/mL (191.08 mM)
Water 41 mg/mL (78.34 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.11 mL 95.55 mL 191.09 mL
0.5 mM 3.82 mL 19.11 mL 38.22 mL
1 mM 1.91 mL 9.55 mL 19.11 mL
5 mM 0.38 mL 1.91 mL 3.82 mL

*The above data is based on the productmolecular weight 523.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10848
MECHANISM OF ACTION Inhibitor
M. Wt 523.3
Formula C16H15F6N5O.H3PO4.H2O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 654671-77-9
Synonyms Januvia, MK-0431
SMILES C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.O.OP(=O)(O)O

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