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Sitaxsentan sodium (TBC-11251)是一种选择性内皮素受体A拮抗剂，IC50和Ki分别为1.4 nM和0.43 nM。
靶点信息
| ET-A | ET-A | |||
| 0.43 nM(Ki) | 1.4 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.97 mL | 104.85 mL | 209.69 mL |
| 0.5 mM | 4.19 mL | 20.97 mL | 41.94 mL |
| 1 mM | 2.1 mL | 10.48 mL | 20.97 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.19 mL |
*The above data is based on the productmolecular weight 476.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11564 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 476.89 |
| Formula | C18H14ClN2NaO6S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 210421-74-2 |
| SMILES | CC1=CC2=C(C=C1CC(=O)C3=C(C=CS3)S(=O)(=O)[N-]C4=C(C(=NO4)C)Cl)OCO2.[Na+] |
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