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SL-327

促销

MKK/MEK 抑制剂

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产品目录号: A14137

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SL-327 10mg A14137-10
¥ 400.00
SL-327 25mg A14137-25
¥ 800.00
SL-327 50mg A14137-50
¥ 2,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

SL-327

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Chemical Information

目录号 A14137
Mechanism of action Inhibitor
分子量 335.4
化学分子式 C16H12F3N3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 305350-87-2
Synonyms SL 327, SL327
SMILES code C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F
化学名称 ??-?[amino[(4-?aminophenyl)thio]methylene]-?2-?(trifluoromethyl)-?benzeneacetonitrile

生物活性

Description
SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Targets
Target Value
MEK1IC50: 0.18μM
MEK2IC50: 0.22μM
AP-1IC50: 2.03μM
PKCIC50: >10μM
MKK3/p38MAPKIC50: 21μM
ERK1IC50: >50μM
MKK4IC50: >100μM
JNKIC50: >100μM

溶解性

Solubility (25°C)* In vitro DMSO 4 mg/mL (11.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (20.87 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.82 mL 149.08 mL 298.15mL
0.5 mM 5.96 mL 29.82 mL 59.63 mL
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL

*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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