SL-327

目录号: A14137

MKK/MEK inhibitor

SL-327 Chemical Structure

CAS NO. 305350-87-2

SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
25 mg
¥ 800.00
50 mg
¥ 2,400.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Targets
Target Value
MEK1IC50: 0.18μM
MEK2IC50: 0.22μM
AP-1IC50: 2.03μM
PKCIC50: >10μM
MKK3/p38MAPKIC50: 21μM
ERK1IC50: >50μM
MKK4IC50: >100μM
JNKIC50: >100μM
In vitro DMSO 4 mg/mL (11.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (20.87 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.82 mL 149.08 mL 298.15 mL
0.5 mM 5.96 mL 29.82 mL 59.63 mL
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL

*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14137
MECHANISM OF ACTION Inhibitor
M. Wt 335.4
Formula C16H12F3N3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 305350-87-2
Synonyms SL 327, SL327
SMILES C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

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