SL-327
目录号: A14137
MKK/MEK 抑制剂
SL-327 是一种选择性的 MEK1 和 MEK2 抑制剂（IC50 值分别为 0.18 和 0.22 μM）；在体外阻断海马长时程增强（LTP）。在体内具有穿透大脑的能力，通过系统给药阻断大鼠的恐惧条件反射和学习，并在小鼠中产生神经保护作用。
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生物活性
| Discription | SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration. | ||
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产品信息
| 目录号 | A14137 |
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| 分子式 | C16H12F3N3S |
| 分子量 | 335.4 |
| CAS号 | 305350-87-2 |
| SMILES | C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F |
| 其他名称 | SL 327, SL327 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 66 mg/mL (196.81 mM) | |
| Water | Insoluble | ||
| Ethanol | 7 mg/mL (20.87 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.82 mL | 149.08 mL | 298.15 mL |
| 0.5 mM | 5.96 mL | 29.82 mL | 59.63 mL |
| 1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
| 5 mM | 0.6 mL | 2.98 mL | 5.96 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 305350-87-2 | 305350-87-2 供应商 | 305350-87-2 花费 | 305350-87-2 生产商 | 订购 305350-87-2 | 305350-87-2 代理商