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SN 38


DNA topoisomerase 抑制剂

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产品目录号: A12011


产品名 目录号 价格 数量
SN 38 50mg A12011-50
¥ 600.00
SN 38 100mg A12011-100
¥ 800.00
SN 38 250mg A12011-250
¥ 1,600.00
SN 38 10mM * 1mL in DMSO A12011-10mM-D
¥ 850.00



SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor).

SN 38




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 SN 38 发表的文献 (2)
  • Alibolandi M, .et al. Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38, Artif Cells Nanomed Biotechnol, 2018, May 27:1-12 PMID: 29806500
  • Bar-Zeev M, .et al. 汕-Casein micelles for oral delivery of SN-38 and elacridar to overcome BCRP-mediated multidrug resistance in gastric cancer, Eur J Pharm Biopharm, 2018, Dec;133:240-249 PMID: 30367935

Chemical Information

目录号 A12011
Mechanism of action Inhibitor
分子量 392.4
化学分子式 C22H20N2O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 86639-52-3
Synonyms 7-Ethyl-10-hydroxycamptothecin, SN38, SN-38
SMILES code CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)O
化学名称 (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione


SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor).
Topo I (Cell-free assay)


Solubility (25°C)* In vitro DMSO 21 mg/mL (53.51 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.48 mL 127.42 mL 254.84mL
0.5 mM 5.1 mL 25.48 mL 50.97 mL
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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