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SNIPER(ABL)-039

SNIPER(ABL)-039

Name: SNIPER(ABL)-039
SKU: A19588

目录号: A19588

SNIPER(ABL)-039 Chemical Structure

CAS NO. 2222354-29-0

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.

库存：现货

规格	价格	数量
1 mg	￥ 3,200.00
5 mg	￥ 9,600.00
10 mg	￥ 16,000.00

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	8.97 mL	44.85 mL	89.7 mL
0.5 mM	1.79 mL	8.97 mL	17.94 mL
1 mM	0.9 mL	4.49 mL	8.97 mL
5 mM	0.18 mL	0.9 mL	1.79 mL

*The above data is based on the productmolecular weight 1114.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A19588
M. Wt	1114.77
Formula	C54H68ClN11O9S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	2222354-29-0
SMILES	CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1