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SNIPER(ABL)-062, in which an ABL inhibitor is linked to a ligand of cIAP1 via a linker containing a variable polyethylene glycol (PEG) unit, shows a potent activity to degrade the BCR-ABL protein.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.18 mL | 45.89 mL | 91.77 mL |
| 0.5 mM | 1.84 mL | 9.18 mL | 18.35 mL |
| 1 mM | 0.92 mL | 4.59 mL | 9.18 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.84 mL |
*The above data is based on the productmolecular weight 1089.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18567 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 1089.64 |
| Formula | C53H63ClF2N10O9S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2140260-89-3 |
| SMILES | O=C(C1CCN(C2=NC=C(C(NC3=CC=C(OC(F)(Cl)F)C=C3)=O)C=C2C4=CC=NN4)C1)NCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5 |
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