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SNS-032 (BMS-387032)

促销

CDK 抑制剂

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产品目录号: A10850

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SNS-032 5mg A10850-5
¥ 400.00
SNS-032 10mg A10850-10
¥ 600.00
SNS-032 50mg A10850-50
¥ 1,800.00
SNS-032 100mg A10850-100
¥ 3,000.00
SNS-032 (BMS-387032) 10mM * 1mL in DMSO A10850-10mM-D
¥ 890.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.

SNS-032 (BMS-387032)

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Chemical Information

目录号 A10850
Mechanism of action Inhibitor
分子量 380.5
化学分子式 C17H24N4O2S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 345627-80-7
Synonyms SNS032, BMS-387032, BMS387032
SMILES code CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
化学名称 N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide

生物活性

Description
SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
Targets
Target Value
CDK9/CyclinTIC50: 4nM
CDK2/CyclinAIC50: 38nM
CDK2/CyclinEIC50: 48nM
CDK7/CyclinHIC50: 62nM
GSK-3αIC50: 230nM
CDK5/p35IC50: 340nM
CDK1/CyclinBIC50: 480nM
GSK-3βIC50: 660nM
CDK4/CyclinDIC50: 925nM
CDK6/CyclinDIC50: >1μM

溶解性

Solubility (25°C) * In vitro DMSO 76 mg/mL (199.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.28 mL 131.41 mL 262.81mL
0.5 mM 5.26 mL 26.28 mL 52.56 mL
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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