|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.|
|Solubility (25°C) *||In vitro||DMSO||105 mg/mL (199.22 mM)|
|Water||6 mg/mL (11.38 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||15% Captisol||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||18.98 mL||94.88 mL||189.75mL|
|0.5 mM||3.8 mL||18.98 mL||37.95 mL|
|1 mM||1.9 mL||9.49 mL||18.98 mL|
|5 mM||0.38 mL||1.9 mL||3.8 mL|
*The above data is based on the productmolecular weight 527.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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