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SNX-2112

促销

Hsp90 抑制剂

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产品目录号: A11189

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SNX-2112 5mg A11189-5
¥ 1,500.00
SNX-2112 10mg A11189-10
¥ 2,200.00
SNX-2112 50mg A11189-50
¥ 5,500.00
SNX-2112 100mg A11189-100
¥ 9,200.00
SNX-2112 10mM * 1mL in DMSO A11189-10mM-D
¥ 1,980.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

SNX-2112

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 SNX-2112 发表的文献 (1)
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107每113

Chemical Information

目录号 A11189
Mechanism of action Inhibitor
分子量 464.48
化学分子式 C23H27F3N4O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 908112-43-6
Synonyms SNX2112, PF 04928473
SMILES code CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
化学名称 2-[(trans-4-Hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]benzamide

生物活性

Description

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

Targets
HSP90α HSP90β
30 nM(Ka)30 nM(Ka)

溶解性

Solubility (25°C) * In vitro DMSO 93 mg/mL (200.22 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.15 mM)
In vivo 0.5% CMC/0.25% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.53 mL 107.65 mL 215.29mL
0.5 mM 4.31 mL 21.53 mL 43.06 mL
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL

*The above data is based on the productmolecular weight 464.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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