SNX-2112

Name: SNX-2112
SKU: A11189

目录号: A11189

Hsp90 抑制剂

Product Citations (2)

SNX-2112 Chemical Structure

CAS NO. 908112-43-6

SNX-2112是目前在临床试验中具有抗癌特性的热激蛋白90（Hsp90）抑制剂。SNX-2112通过Akt/mTOR/p70S6K抑制以时间和剂量依赖的方式诱导自噬。SNX-2112在人黑素瘤A-375细胞中诱导明显的凋亡和自噬，可能是有效的靶向治疗剂。

库存：现货

规格	价格	数量
5 mg	￥ 1,500.00
10 mg	￥ 2,200.00
50 mg	￥ 5,500.00
100 mg	￥ 9,200.00
10mM * 1mL in DMSO	￥ 1,980.00

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生物活性

靶点信息

HSP90α	HSP90β
30 nM(Ka)	30 nM(Ka)

溶解度 *

In vitro (25°C)	DMSO	90 mg/mL (193.76 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (2.15 mM)
In vivo	0.5% CMC+0.25% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.53 mL	107.65 mL	215.29 mL
0.5 mM	4.31 mL	21.53 mL	43.06 mL
1 mM	2.15 mL	10.76 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL

*The above data is based on the productmolecular weight 464.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11189
作用机制	Inhibitor (抑制剂)
M. Wt	464.48
Formula	C23H27F3N4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	908112-43-6
Synonyms	SNX2112, PF 04928473
SMILES	CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C