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Sodium succinate dibasic is an inhibitor of multiple receptor tyrosine kinases. Sodium succinate dibasic is known to be a potent inhibitor of Met, Flt-1 (VEGFR1), Flk-1 (VEGFR2), Flt-3 (VEGFR3), Ron, and Tie-2. Sodium succinate dibasic has been observed to inhibit Met (c-Met)-driven tumor cell and non-c-Met driven tumor cell (HCT116 and MDA-MB-231) proliferation. This product has also been observed to effectively inhibit c-Met phosphorylation and its downstream signaling pathways in serum starved MKN45 cells, as well as inducing apoptosis in these cells.
| In vitro | DMSO | Insoluble | |
| Water | 31 mg/mL (191.29 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 61.71 mL | 308.55 mL | 617.09 mL |
| 0.5 mM | 12.34 mL | 61.71 mL | 123.42 mL |
| 1 mM | 6.17 mL | 30.85 mL | 61.71 mL |
| 5 mM | 1.23 mL | 6.17 mL | 12.34 mL |
*The above data is based on the productmolecular weight 162.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17952 |
|---|---|
| M. Wt | 162.05 |
| Formula | C4H4Na2O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 150-90-3 |
| Synonyms | Butanedioic acid, disodium salt; CCRIS 3700; CCRIS-3700; CCRIS3700; Disodium succinate; Jantaran sodny; Soduxin; Disodium succinate; Disodium butanedioate; |
| SMILES | O=C([O-])CCC([O-])=O.[Na+].[Na+] |
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