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Sorafenib (Nexavar)

促销

Raf 抑制剂

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产品目录号: A10001

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Sorafenib (Nexavar) 100mg A10001-100
¥ 500.00
Sorafenib 10mM * 1mL in DMSO A10001-10mM-D
¥ 1,100.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.

Sorafenib (Nexavar)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Sorafenib (Nexavar) 发表的文献 (7)
  • Fangyuan Lai, .et al. Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways, Stem Cell Res Ther, 2018, 9: 107 PMID: 29661222
  • Arum Park, .et al. Identification of Transcription Factor YY1 as a Regulator of a Prostate Cancer-Specific Pathway Using Proteomic Analysis, J Cancer, 2017 ㄗ帤梑善ㄘ, 8(12): 2303每2311 PMID: 28819434
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
  • Zhihong Li, .et al. Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3., J Med Chem., 2014, Apr 24;57(8):3430-49. PMID: 24641103
  • Hideki Yamaguchi, .et al. Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors, Cancer Sci, 2014, 105(5): 528每536 PMID: 24612061
  • Yaping Zhang, .et al. FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia, J Pharmacokinet Pharmacodyn., 2014, 41(6): 675每691. PMID: 25326874

Chemical Information

目录号 A10001
Mechanism of action Inhibitor
分子量 637
化学分子式 C21H16ClF3N4O3.C7H8O3S
Solubility DMSO>127mg/mL Water <1mg/mL Ethanol <1mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 475207-59-1
Synonyms Bay 43-9006
SMILES code a
化学名称 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

生物活性

Description
Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
Targets
Target Value
Raf-1IC50: 6nM
VEGFR2/Flk1IC50: 15nM
B-RafIC50: 22nM
B-Raf(V599E)IC50: 38nM
PDGFRβIC50: 57nM
mPDGFRβIC50: 57nM
FLT3IC50: 58nM
c-KitIC50: 68nM
VEGFR2IC50: 90nM
FGFR1IC50: 580nM
ERK1IC50: >10μM
MEK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
IGF-1RIC50: >10μM
c-MetIC50: >10μM
PKBIC50: >10μM
PKAIC50: >10μM
CDK1/CyclinBIC50: >10μM
PKCαIC50: >10μM
PKCγIC50: >10μM
Pim1IC50: >10μM

溶解性

Solubility (25°C)* In vitro DMSO 63 mg/mL heating (135.53 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.7 mL 78.49 mL 156.99mL
0.5 mM 3.14 mL 15.7 mL 31.4 mL
1 mM 1.57 mL 7.85 mL 15.7 mL
5 mM 0.31 mL 1.57 mL 3.14 mL

*The above data is based on the productmolecular weight 637. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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