Sorafenib Tosylate (Nexavar)

目录号: A10001

Raf 抑制剂

Sorafenib Tosylate (Nexavar)

Sorafenib Tosylate (Nexavar) Chemical Structure

CAS NO. 475207-59-1

Sorafenib Tosylate (Nexavar)是几种酪氨酸蛋白激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂的新型小分子抑制剂,Raf-1,wt BRAF和V599E突变型BRAF的IC50为6、22、38 nM。

库存: 现货

规格 价格 数量
100 mg
¥ 500.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Sorafenib Tosylate (Nexavar)是几种酪氨酸蛋白激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂的新型小分子抑制剂,Raf-1,wt BRAF和V599E突变型BRAF的IC50为6、22、38 nM。
Targets
Target Value
Raf-1IC50: 6nM
VEGFR2/Flk1IC50: 15nM
B-RafIC50: 22nM
B-Raf(V599E)IC50: 38nM
PDGFRβIC50: 57nM
mPDGFRβIC50: 57nM
FLT3IC50: 58nM
c-KitIC50: 68nM
VEGFR2IC50: 90nM
FGFR1IC50: 580nM
ERK1IC50: >10μM
MEK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
IGF-1RIC50: >10μM
c-MetIC50: >10μM
PKBIC50: >10μM
PKAIC50: >10μM
CDK1/CyclinBIC50: >10μM
PKCαIC50: >10μM
PKCγIC50: >10μM
Pim1IC50: >10μM
In vitro (25°C) DMSO 114 mg/mL (178.95 mM)
Water <1 mg/mL
Ethanol Insoluble
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.7 mL 78.49 mL 156.99 mL
0.5 mM 3.14 mL 15.7 mL 31.4 mL
1 mM 1.57 mL 7.85 mL 15.7 mL
5 mM 0.31 mL 1.57 mL 3.14 mL

*The above data is based on the productmolecular weight 637. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10001
作用机制 Inhibitor (抑制剂)
M. Wt 637
Formula C21H16ClF3N4O3.C7H8O3S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 475207-59-1
Synonyms Bay 43-9006
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

产品标签

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Product Questions

Product Questions

No Questions
Keywords:购买 Sorafenib Tosylate (Nexavar) | Sorafenib Tosylate (Nexavar) 供应商 | 订购 Sorafenib Tosylate (Nexavar) | Sorafenib Tosylate (Nexavar) 价格 | Sorafenib Tosylate (Nexavar) 生产商 | 订单 Sorafenib Tosylate (Nexavar) | Sorafenib Tosylate (Nexavar) 代理商 | 购买 475207-59-1| 475207-59-1 供应商 | 订购 475207-59-1 | 475207-59-1 价格 | 475207-59-1 生产商 | 订单 475207-59-1 | 475207-59-1 代理商|buy Sorafenib Tosylate (Nexavar) | Sorafenib Tosylate (Nexavar) Supplier | purchase Sorafenib Tosylate (Nexavar) | Sorafenib Tosylate (Nexavar) cost | Sorafenib Tosylate (Nexavar) manufacturer | order Sorafenib Tosylate (Nexavar) | Sorafenib Tosylate (Nexavar) distributor | buy 475207-59-1| 475207-59-1 Supplier | purchase 475207-59-1 | 475207-59-1 cost | 475207-59-1 manufacturer | order 475207-59-1 | 475207-59-1 distributor
Rewards