SP600125

目录号: A10860

JNK inhibitor

SP600125 Chemical Structure

CAS NO. 129-56-6

SP600125是一种JNK抑制剂,对于JNK-1和JNK-2,IC50 = 40 nM,对于JNK-3,IC50 = 90 nM。

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
50 mg
¥ 550.00
200 mg
¥ 1,000.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

SP600125是一种JNK抑制剂,对于JNK-1和JNK-2,IC50 = 40 nM,对于JNK-3,IC50 = 90 nM。
Targets
Target Value
JNK1IC50: 40nM
JNK2IC50: 40nM
AuroraAIC50: 60nM
TrkAIC50: 70nM
JNK3IC50: 90nM
FLT3IC50: 90nM
MKK4IC50: 0.4μM
MKK6IC50: 1.0μM
PKBIC50: 1.0μM
MKK3IC50: 1.5μM
PKCαIC50: 1.5μM
p56LCKIC50: 4.3μM
MKK7IC50: 5.1μM
MEKK1IC50: >10μM
ERK2IC50: >10μM
p38βIC50: >10μM
PKAIC50: >10μM
PKCIC50: >10μM
PKCθIC50: >10μM
Chk1IC50: >10μM
EGFIC50: >10μM
IKK1IC50: >10μM
IKK2IC50: >10μM
In vitro (25°C) DMSO 44 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 45.41 mL 227.07 mL 454.13 mL
0.5 mM 9.08 mL 45.41 mL 90.83 mL
1 mM 4.54 mL 22.71 mL 45.41 mL
5 mM 0.91 mL 4.54 mL 9.08 mL

*The above data is based on the productmolecular weight 220.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10860
MECHANISM OF ACTION Inhibitor
M. Wt 220.2
Formula C14H8N2O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 129-56-6
Synonyms N/A
SMILES C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O

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