Spesolimab (BI 655130) is a humanized IgG1?? monoclonal antibody derived from mouse sources, targeting the interleukin-36 receptor (IL-36R). IL-36 is critical in mediating immune responses, and Spesolimab has shown potential efficacy in clinical studies for the treatment of palmoplantar pustulosis (PPP). The therapeutic action of Spesolimab includes the modulation of biomarkers linked to innate immunity and Th1/Th17 and neutrophil pathways, suggesting its role in altering inflammatory processes. This antibody is currently under investigation for its therapeutic potential and mechanism of action in immune-mediated dermatological conditions.
Spesolimab (BI 655130) is a humanized IgG1?? monoclonal antibody derived from mouse sources, targeting the interleukin-36 receptor (IL-36R). IL-36 is critical in mediating immune responses, and Spesolimab has shown potential efficacy in clinical studies for the treatment of palmoplantar pustulosis (PPP). The therapeutic action of Spesolimab includes the modulation of biomarkers linked to innate immunity and Th1/Th17 and neutrophil pathways, suggesting its role in altering inflammatory processes. This antibody is currently under investigation for its therapeutic potential and mechanism of action in immune-mediated dermatological conditions.
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