产品详情

生物活性

SRPIN340是一种细胞可渗透的异烟酰胺，可作为ATP竞争性SRPK1选择性抑制剂（对mSRPK1和mSRPK2分别为IC50 = 0.14和1.8μM），对143种其他激酶的活性大大降低。

靶点信息

SRPK1
0.89 μM(Ki)

溶解度 *

In vitro (25°C)	DMSO	67 mg/mL (191.78 mM)
	Water	Insoluble
	Ethanol	67 mg/mL (191.78 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.62 mL	143.1 mL	286.2 mL
0.5 mM	5.72 mL	28.62 mL	57.24 mL
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL

*The above data is based on the productmolecular weight 349.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13188
作用机制	Inhibitor (抑制剂)
M. Wt	349.4
Formula	C18H18F3N3O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	218156-96-8
Synonyms	SRPIN 340, SRPIN-340
SMILES	C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3