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SRT1720 HCl


SIRT1 Activator

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产品目录号: A10862


产品名 目录号 价格 数量
SRT1720 5mg A10862-5
¥ 900.00
SRT1720 10mg A10862-10
¥ 1,600.00
SRT1720 50mg A10862-50
¥ 4,500.00
SRT1720 200mg A10862-200
¥ 12,000.00
SRT1720 10mM * 1mL in DMSO A10862-10mM-D
¥ 1,500.00



SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.

SRT1720 HCl




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 SRT1720 HCl 发表的文献 (6)
  • Jie Ren, .et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 PMID: 30411173
  • Rowlands BD, .et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
  • Adam Khader, .et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
  • Adam Khader, .et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651每e663 PMID: 26963320
  • Benjamin D. Rowlands, .et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
  • Khader A, .et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 PMID: 24918615

Chemical Information

目录号 A10862
Mechanism of action Activator
分子量 506.0
化学分子式 C25H23N7OS.HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1001645-58-4
Synonyms SRT-1720
化学名称 N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide


SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
SIRT1 (Cell-free assay)
0.16 μM(EC50)


Solubility (25°C) * In vitro DMSO 38 mg/mL (75.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.76 mL 98.81 mL 197.63mL
0.5 mM 3.95 mL 19.76 mL 39.53 mL
1 mM 1.98 mL 9.88 mL 19.76 mL
5 mM 0.4 mL 1.98 mL 3.95 mL

*The above data is based on the productmolecular weight 506.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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