产品详情

生物活性

Stattic是第一个非肽类STAT3小分子抑制剂，有效抑制STAT3激活和核易位，IC50为5.1 μM，可通过阻断磷酸化和二聚化事件来选择性抑制Stat3转录因子的激活。

靶点信息

STAT3 (Cell-free assay)
5.1 μM

溶解度 *

In vitro (25°C)	DMSO	38 mg/mL (179.93 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	47.35 mL	236.75 mL	473.51 mL
0.5 mM	9.47 mL	47.35 mL	94.7 mL
1 mM	4.74 mL	23.68 mL	47.35 mL
5 mM	0.95 mL	4.74 mL	9.47 mL

*The above data is based on the productmolecular weight 211.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12733
作用机制	Inhibitor (抑制剂)
M. Wt	211.19
Formula	C8H5NO4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	19983-44-9
Synonyms	STAT3 Inhibitor V
SMILES	C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]