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Staurosporine

促销

PKC 抑制剂

158 Customer Reviews
产品目录号: A10864

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Staurosporine 5mg A10864-5
¥ 1,100.00
Staurosporine 10mg A10864-10
¥ 1,500.00
Staurosporine 25mg A10864-25
¥ 3,000.00
Staurosporine 50mg A10864-50
¥ 5,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.

Staurosporine

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Staurosporine 发表的文献 (2)
  • Jacobs CL, .et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 PMID: 29967496
  • Birte Plitzko, .et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells, J Biol Chem, 2017, Dec 22; 292(51): 21102每21116 PMID: 29074620

Chemical Information

目录号 A10864
Mechanism of action Inhibitor
分子量 466.5
化学分子式 C28H26N4O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 62996-74-1
Synonyms AM-2282, STS
SMILES code C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
化学名称 (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

生物活性

Description
Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.
Targets
Target Value
PKCαIC50: 2nM
c-FgrIC50: 2nM
phosphorylasekinaseIC50: 3nM
PKCηIC50: 4nM
PKCγIC50: 5nM
S6kinaseIC50: 5nM
v-SrcIC50: 6nM
Cdc2IC50: 9nM
Cdc2IC50: 9nM
PKAIC50: 15nM
SykIC50: 16nM
PKGIC50: 18nM
PKCδIC50: 20nM
CaMKIIIC50: 20nM
LynIC50: 20nM
MLCKIC50: 21nM
PKCεIC50: 73nM
PKCζIC50: 1086nM

溶解性

Solubility (25°C)* In vitro DMSO 4 mg/mL (8.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.44 mL 107.18 mL 214.36mL
0.5 mM 4.29 mL 21.44 mL 42.87 mL
1 mM 2.14 mL 10.72 mL 21.44 mL
5 mM 0.43 mL 2.14 mL 4.29 mL

*The above data is based on the productmolecular weight 466.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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