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SU11274

促销

c-Met 抑制剂

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产品目录号: A10869

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SU11274 5mg A10869-5
¥ 600.00
SU11274 10mg A10869-10
¥ 1,100.00
SU11274 50mg A10869-50
¥ 4,800.00
SU11274 100mg A10869-100
¥ 7,000.00
SU11274 10mM * 1mL in DMSO A10869-10mM-D
¥ 1,270.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SU11274 is a Met tyrosine kinase inhibitor.

SU11274

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Chemical Information

目录号 A10869
Mechanism of action Inhibitor
分子量 568.1
化学分子式 C28H30CIN5O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 658084-23-2
Synonyms SU-11274, PKI-SU11274
SMILES code CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C\3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
化学名称 (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide

生物活性

Description
SU11274 is a Met tyrosine kinase inhibitor.
Targets
Target Value
MetIC50: 0.01μM
Flk1IC50: 1.25μM
RONIC50: 4.0μM
FGFR1IC50: 8.5μM
CDK2IC50: >10μM
PDGFRβIC50: >20μM
EGFRIC50: >100μM

溶解性

Solubility (25°C) * In vitro DMSO 92 mg/mL (161.94 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (3.52 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.6 mL 88.01 mL 176.03mL
0.5 mM 3.52 mL 17.6 mL 35.21 mL
1 mM 1.76 mL 8.8 mL 17.6 mL
5 mM 0.35 mL 1.76 mL 3.52 mL

*The above data is based on the productmolecular weight 568.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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