产品详情

生物活性

SU11274是一种Met酪氨酸激酶抑制剂。

Targets

Target	Value
Met	IC50: 0.01μM
Flk1	IC50: 1.25μM
RON	IC50: 4.0μM
FGFR1	IC50: 8.5μM
CDK2	IC50: >10μM
PDGFRβ	IC50: >20μM
EGFR	IC50: >100μM

溶解度 *

In vitro (25°C)	DMSO	83 mg/mL (146.1 mM)
	Water	Insoluble
	Ethanol	2 mg/mL
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.6 mL	88.01 mL	176.03 mL
0.5 mM	3.52 mL	17.6 mL	35.21 mL
1 mM	1.76 mL	8.8 mL	17.6 mL
5 mM	0.35 mL	1.76 mL	3.52 mL

*The above data is based on the productmolecular weight 568.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10869
作用机制	Inhibitor (抑制剂)
M. Wt	568.1
Formula	C28H30CIN5O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	658084-23-2
Synonyms	SU-11274, PKI-SU11274
SMILES	CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C\3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O