Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody that specifically targets the T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). This antibody exhibits a high affinity for the extracellular domain of human TIM-3, with a dissociation constant (K_D) of 0.36 nM, indicating strong and specific binding. Surzebiclimab is primarily utilized in the research of cancer immunotherapy, exploring pathways for enhancing immune responses against tumors.
Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody that specifically targets the T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). This antibody exhibits a high affinity for the extracellular domain of human TIM-3, with a dissociation constant (K_D) of 0.36 nM, indicating strong and specific binding. Surzebiclimab is primarily utilized in the research of cancer immunotherapy, exploring pathways for enhancing immune responses against tumors.
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