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T0070907

促销

PPAR-?? 拮抗剂

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产品目录号: A11588

库存状态:中国现货中国现货

产品名 目录号 价格 数量
T0070907 5mg A11588-5
¥ 400.00
T0070907 10mg A11588-10
¥ 600.00
T0070907 50mg A11588-50
¥ 2,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.

T0070907

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Chemical Information

目录号 A11588
Mechanism of action Antagonist
分子量 277.66
化学分子式 C12H8ClN3O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 313516-66-4
Synonyms T 0070907
SMILES code ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=CC=NC=C2)=O
化学名称 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide

生物活性

Description
T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
Targets
PPARγ (Cell-free assay) PPARα (Cell-free assay) PPARδ (Cell-free assay)
1 nM0.85 μM1.8 μM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.02 mL 180.08 mL 360.15mL
0.5 mM 7.2 mL 36.02 mL 72.03 mL
1 mM 3.6 mL 18.01 mL 36.02 mL
5 mM 0.72 mL 3.6 mL 7.2 mL

*The above data is based on the productmolecular weight 277.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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