Tadalafil
目录号: A10883
PDE5 抑制剂
Tadalafil 是一种 PDE5 抑制剂，其 IC50 值为 1.8 nM。
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生物活性
| Discription | Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM. | ||
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| Targets |
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产品信息
| 目录号 | A10883 |
|---|---|
| 分子式 | C22H19N3O4 |
| 分子量 | 389.4 |
| CAS号 | 171596-29-5 |
| SMILES | CN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36 |
| 其他名称 | Adcirca, Cialis |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 70 mg/mL (179.76 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.68 mL | 128.4 mL | 256.81 mL |
| 0.5 mM | 5.14 mL | 25.68 mL | 51.36 mL |
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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