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ALK 抑制剂

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产品目录号: A10662


产品名 目录号 价格 数量
TAE684 5mg A10662-5
¥ 800.00
TAE684 10mg A10662-10
¥ 1,200.00
TAE684 50mg A10662-50
¥ 3,200.00
TAE684 100mg A10662-100
¥ 4,500.00



TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 TAE684 发表的文献 (2)
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190

Chemical Information

目录号 A10662
Mechanism of action Inhibitor
分子量 614.2
化学分子式 C30H40ClN7O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 761439-42-3
Synonyms NVP-TAE684 , TAE-684
化学名称 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine


TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).
ALK (Cell-free assay)
3 nM


Solubility (25°C) * In vitro DMSO 3 mg/mL (4.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, pH 4 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.28 mL 81.41 mL 162.81mL
0.5 mM 3.26 mL 16.28 mL 32.56 mL
1 mM 1.63 mL 8.14 mL 16.28 mL
5 mM 0.33 mL 1.63 mL 3.26 mL

*The above data is based on the productmolecular weight 614.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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