TAK-285

目录号: A11236

HER2/EGFR 抑制剂

TAK-285

TAK-285 Chemical Structure

CAS NO. 871026-44-7

TAK-285是一种研究性的HER2/EGFR抑制剂,可在具有完整血脑屏障 (BBB) 的大鼠中穿透CNS。TAK-285对HER2和EGFR激酶具有抑制活性,HER2和EGFR的IC50值分别为17 nmol/L (95%CI 12-24)和23 nmol/L (95%CI 18-30)。

库存: 现货

规格 价格 数量
5 mg
¥ 1,800.00
10 mg
¥ 3,000.00
25 mg
¥ 5,800.00
50 mg
¥ 9,800.00
10mM * 1mL in DMSO
¥ 2,560.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

TAK-285是一种研究性的HER2/EGFR抑制剂,可在具有完整血脑屏障 (BBB) 的大鼠中穿透CNS。TAK-285对HER2和EGFR激酶具有抑制活性,HER2和EGFR的IC50值分别为17 nmol/L (95%CI 12-24)和23 nmol/L (95%CI 18-30)。
Targets
Target Value
HER2IC50: 17nM
EGFR/HER1IC50: 23nM
HER4IC50: 260nM
MEK1IC50: 1.1μM
AuroraBIC50: 1.7μM
LCKIC50: 2.4μM
c-MetIC50: 4.2μM
CSKIC50: 4.7μM
LynBIC50: 5.2μM
MEK5IC50: 5.7μM
LynAIC50: >10μM
FAKIC50: >10μM
VEGFR1IC50: >10μM
VEGFR2IC50: >10μM
FGFR1IC50: >10μM
FGFR3IC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
IRKIC50: >10μM
Tie-2IC50: >10μM
c-KitIC50: >10μM
IGF-1RIC50: >10μM
SrcIC50: >10μM
ASK1IC50: >10μM
TAK1IC50: >10μM
MEKK1IC50: >10μM
IKKβIC50: >10μM
JNK1IC50: >10μM
ERK1IC50: >10μM
p38αIC50: >10μM
PKAIC50: >10μM
PKCθIC50: >10μM
GSK-3βIC50: >10μM
B-RafIC50: >10μM
TTKIC50: >10μM
PLK1IC50: >10μM
In vitro DMSO 110 mg/mL (200.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 54 mg/mL (98.54 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.25 mL 91.24 mL 182.48 mL
0.5 mM 3.65 mL 18.25 mL 36.5 mL
1 mM 1.82 mL 9.12 mL 18.25 mL
5 mM 0.36 mL 1.82 mL 3.65 mL

*The above data is based on the productmolecular weight 548.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11236
作用机制 Inhibitor (抑制剂)
M. Wt 548.0
Formula C26H25ClF3N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 871026-44-7
Synonyms TAK285
SMILES CC(C)(CC(=O)NCCN1C=CC2=C1C(=NC=N2)NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)O
1. Shinji Takagi, Hiroshi Banno, Akira Hayashi, Toshiya Tamura, Tomoyasu Ishikawa, Yoshikazu Ohta., HER2 and HER3 cooperatively regulate cancer cell growth and determine sensitivity to the novel investigational EGFR/HER2 kinase inhibitor TAK-285. Oncoscience, 2014. 1(3): p. 196-204.

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