TAK-632

目录号: A13323

pan-RAF inhibitor

TAK-632 Chemical Structure

CAS NO. 1228591-30-7

TAK-632 is a potent pan-RAF inhibitor with favorable in
vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.

库存: 现货

规格 价格 数量
5 mg
¥ 650.00
10 mg
¥ 1,000.00
25 mg
¥ 2,000.00
50 mg
¥ 3,000.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.
Targets
Target Value
C-RafIC50: 1.4nM
B-RafIC50: 8.3nM
AuroraBIC50: 66nM
PDGFRβIC50: 120nM
FGFR3IC50: 280nM
GSK-3βIC50: 500nM
CDK2IC50: 580nM
p38αIC50: 600nM
PDGFRαIC50: 610nM
Tie-2IC50: 740nM
CDK1IC50: 790nM
Chk1IC50: 1.4μM
MEK1IC50: 3.7μM
IKKβIC50: 3.7μM
PKAIC50: >10μM
PKCθIC50: >10μM
CK1δIC50: >10μM
ERK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
JNK1IC50: >10μM
c-MetIC50: >10μM
c-KitIC50: >10μM
SrcIC50: >10μM
IRIC50: >10μM
MEKK1IC50: >10μM
In vitro (25°C) DMSO 100 mg/mL (180.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (3.6 mM)
In vivo 2% DMSO/98% PEG 300 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.17 mL 180.34 mL
0.5 mM 3.61 mL 18.03 mL 36.07 mL
1 mM 1.8 mL 9.02 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

*The above data is based on the productmolecular weight 554.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13323
MECHANISM OF ACTION Inhibitor
M. Wt 554.51
Formula C27H18F4N4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1228591-30-7
Synonyms TAK 632; TAK632
SMILES C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N

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