Trusted by 10,000+ Scientists since 2006


pan-RAF 抑制剂

0 Customer Reviews
产品目录号: A13323


产品名 目录号 价格 数量
TAK-632 5mg A13323-5
¥ 650.00
TAK-632 10mg A13323-10
¥ 1,000.00
TAK-632 25mg A13323-25
¥ 2,000.00
TAK-632 50mg A13323-50
¥ 3,000.00
TAK-632 10mM * 1mL in DMSO A13323-10mM-D
¥ 800.00



TAK-632 is a potent pan-RAF inhibitor with favorable in
vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 TAK-632 发表的文献 (1)
  • Yosi Shamay, .et al. Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines, Nat Mater, 2018, Apr; 17(4): 361每368 PMID: 29403054

Chemical Information

目录号 A13323
Mechanism of action Inhibitor
分子量 554.51
化学分子式 C27H18F4N4O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1228591-30-7
Synonyms TAK 632; TAK632
SMILES code C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N
化学名称 N-(7-cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide


TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.
Target Value
C-RafIC50: 1.4nM
B-RafIC50: 8.3nM
AuroraBIC50: 66nM
PDGFRβIC50: 120nM
FGFR3IC50: 280nM
GSK-3βIC50: 500nM
CDK2IC50: 580nM
p38αIC50: 600nM
PDGFRαIC50: 610nM
Tie-2IC50: 740nM
CDK1IC50: 790nM
Chk1IC50: 1.4μM
MEK1IC50: 3.7μM
IKKβIC50: 3.7μM
PKAIC50: >10μM
PKCθIC50: >10μM
CK1δIC50: >10μM
ERK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
JNK1IC50: >10μM
c-MetIC50: >10μM
c-KitIC50: >10μM
SrcIC50: >10μM
IRIC50: >10μM
MEKK1IC50: >10μM


Solubility (25°C) * In vitro DMSO 100 mg/mL (180.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (3.6 mM)
In vivo 2% DMSO/98% PEG 300 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.17 mL 180.34mL
0.5 mM 3.61 mL 18.03 mL 36.07 mL
1 mM 1.8 mL 9.02 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

*The above data is based on the productmolecular weight 554.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.



Similar product(s)

Keywords:购买 TAK-632 | TAK-632 供应商 | 订购 TAK-632 | TAK-632 价格 | TAK-632 生产商 | 订单 TAK-632 | TAK-632 代理商 | 购买 1228591-30-7| 1228591-30-7 供应商 | 订购 1228591-30-7 | 1228591-30-7 价格 | 1228591-30-7 生产商 | 订单 1228591-30-7 | 1228591-30-7 代理商|buy TAK-632 | TAK-632 Supplier | purchase TAK-632 | TAK-632 cost | TAK-632 manufacturer | order TAK-632 | TAK-632 distributor | buy 1228591-30-7| 1228591-30-7 Supplier | purchase 1228591-30-7 | 1228591-30-7 cost | 1228591-30-7 manufacturer | order 1228591-30-7 | 1228591-30-7 distributor