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TAK-715

促销

p38 MAPK 抑制剂

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产品目录号: A11582

库存状态:中国现货中国现货

产品名 目录号 价格 数量
TAK-715 10mg A11582-10
¥ 1,100.00
TAK-715 25mg A11582-25
¥ 2,200.00
TAK-715 50mg A11582-50
¥ 3,200.00
TAK-715 100mg A11582-100
¥ 5,500.00
TAK-715 10mM * 1mL in DMSO A11582-10mM-D
¥ 800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.

TAK-715

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Chemical Information

目录号 A11582
Mechanism of action Inhibitor
分子量 399.51
化学分子式 C24H21N3OS
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 303162-79-0
Synonyms TAK715, TAK 715
SMILES code CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C
化学名称 N-(4-(2-Ethyl-4-(3-methylphenyl)-thiazol-5-yl)pyridin-2-yl)benzamide

生物活性

Description
TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.
Targets
Target Value
p38αIC50: 7.1nM
p38βIC50: 0.20μM
p38γIC50: >10μM
p38δIC50: >10μM
JNK1IC50: >10μM
ERK1IC50: >10μM
IKKβIC50: >10μM
MEKK1IC50: >10μM
TAK1IC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 80 mg/mL (200.24 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (40.04 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.03 mL 125.15 mL 250.31mL
0.5 mM 5.01 mL 25.03 mL 50.06 mL
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL

*The above data is based on the productmolecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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