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Tandutinib (MLN518)


FLT3 抑制剂

158 Customer Reviews
产品目录号: A10887


产品名 目录号 价格 数量
Tandutinib 25mg A10887-25
¥ 400.00
Tandutinib 50mg A10887-50
¥ 500.00
Tandutinib 100mg A10887-100
¥ 800.00
Tandutinib 200mg A10887-200
¥ 1,400.00



Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.

Tandutinib (MLN518)




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Chemical Information

目录号 A10887
Mechanism of action Inhibitor
分子量 562.7
化学分子式 C31H42N6O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 387867-13-2
Synonyms MLN-518, CT53518
化学名称 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide; (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide


Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.
Target Value
c-KitIC50: 0.17μM
PDGFRβIC50: 0.20μM
FLT3IC50: 0.22μM
CSF-1RIC50: 3.43μM
SrcIC50: 30μM
AblIC50: >30μM
PKCIC50: >30μM
PKAIC50: >30μM
MEK1IC50: >30μM
MKK4IC50: >30μM
MKK6IC50: >30μM
ERK2IC50: >30μM
p38IC50: >30μM
KDRIC50: >30μM
EGFRIC50: >30μM
FGFRIC50: >30μM
Insulin ReceptorIC50: >30μM


Solubility (25°C) * In vitro DMSO 5 mg/mL (8.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (10.66 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.77 mL 88.86 mL 177.71mL
0.5 mM 3.55 mL 17.77 mL 35.54 mL
1 mM 1.78 mL 8.89 mL 17.77 mL
5 mM 0.36 mL 1.78 mL 3.55 mL

*The above data is based on the productmolecular weight 562.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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