Tat-beclin 1
目录号: A22737
Tat-beclin 1,一种从自噬蛋白(beclin 1)的一个区域衍生的肽,是一个强效的自噬诱导剂,并与自噬的负调控因子GAPR-1(GLIPR2)相互作用。Tat-beclin 1减少了聚谷氨酸扩展蛋白聚集体的积累以及多种病原体(包括HIV-1)在体外的复制,并且在感染基孔肯雅病毒(CHIKV)或西尼罗病毒(WNV)的小鼠中减少了死亡率。
Discription | Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV). |
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目录号 | A22737 |
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分子式 | C164H251N57O45 |
分子量 | 3741.1 |
CAS号 | 1423821-88-8 |
Sequence | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr |
Sequence shortening | YGRKKRRQRRRGGTNVFNATFEIWHDGEFGT |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2