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TC-E 5001

TNKS 抑制剂

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产品目录号: A11454

库存状态:中国现货中国现货

产品名 目录号 价格 数量
TC-E 5001 5mg A11454-5
¥ 800.00
TC-E 5001 10mg A11454-10
¥ 1,400.00
TC-E 5001 50mg A11454-50
¥ 5,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.

TC-E 5001

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Chemical Information

目录号 A11454
Mechanism of action Inhibitor
分子量 409.46
化学分子式 C20H19N5O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 865565-29-3
Synonyms TC-E5001, TC-E-5001
SMILES code CC(N1C(C=C2)=CC=C2OC)=NN=C1SCC3=NC(C(C=C4)=CC=C4OC)=NO3
化学名称 3-(4-methoxyphenyl)-5-(((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)-1,2,4-oxadiazole

生物活性

Description
TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.11 mL 244.22mL
0.5 mM 4.88 mL 24.42 mL 48.84 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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