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TCS 21311

JAK3 抑制剂

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产品目录号: A15365

库存状态:中国现货中国现货

产品名 目录号 价格 数量
TCS 21311 10mg A15365-10
¥ 1,900.00
TCS 21311 50mg A15365-50
¥ 7,900.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively).

TCS 21311

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Chemical Information

目录号 A15365
Mechanism of action Inhibitor
分子量 526.51
化学分子式 C27H25F3N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1260181-14-3
Synonyms TCS21311, TCS-21311
SMILES code CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O
化学名称 3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione

生物活性

Description
TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively).

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.99 mL 94.96 mL 189.93mL
0.5 mM 3.8 mL 18.99 mL 37.99 mL
1 mM 1.9 mL 9.5 mL 18.99 mL
5 mM 0.38 mL 1.9 mL 3.8 mL

*The above data is based on the productmolecular weight 526.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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