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TCS ERK 11e (VX-11e)

促销

ERK2 抑制剂

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产品目录号: A12505

库存状态:中国现货中国现货

产品名 目录号 价格 数量
TCS ERK 11e (VX-11e) 10mg A12505-10
¥ 1,500.00
TCS ERK 11e (VX-11e) 25mg A12505-25
¥ 3,000.00
TCS ERK 11e (VX-11e) 50mg A12505-50
¥ 5,000.00
TCS ERK 11e (VX-11e) 100mg A12505-100
¥ 8,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).

TCS ERK 11e (VX-11e)

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Chemical Information

目录号 A12505
Mechanism of action Inhibitor
分子量 500.35
化学分子式 C24H20Cl2FN5O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 896720-20-0
Synonyms N/A
SMILES code CC1=CN=C(N=C1C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl
化学名称 4-[2-[(2-Chloro-4-fluorophenyl)amin?o]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophen?yl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

生物活性

Description
TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
Targets
Target Value
ERK2ki: <2nM
GSK3ki: 400nM
AURAki: 540nM
CDK2ki: 850nM
FLT3ki: 1.4μM
ROCK1ki: 1.4μM
JNK3ki: 1.4μM
TAK1ki: 3μM
PKAki: >4μM
SRCki: >4μM
JAK2ki: >4μM
JAK3ki: >4μM
SYKki: >4μM
METki: >4μM
IRAK4ki: >4μM
AKT3ki: >4μM
KDRki: >4μM
MEK1ki: >4μM
P38αki: >4μM
COTki: >4μM
ITKki: >4μM
MEKK3ki: >4μM
PLK1ki: >4μM
ZAP70ki: >4μM
IKki: ki: >5μM
NIKki: >5μM
CITki: >10μM
FAKki: >10μM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.99 mL 99.93 mL 199.86mL
0.5 mM 4 mL 19.99 mL 39.97 mL
1 mM 2 mL 9.99 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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