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Tegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.81 mL | 129.07 mL | 258.14 mL |
| 0.5 mM | 5.16 mL | 25.81 mL | 51.63 mL |
| 1 mM | 2.58 mL | 12.91 mL | 25.81 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.16 mL |
*The above data is based on the productmolecular weight 387.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20873 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 387.38 |
| Formula | C20H19F2N3O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 942195-55-3 |
| SMILES | FC1=CC(F)=C2[C@@H](OC3=CC(C(N(C)C)=O)=CC4=C3N=C(C)N4)CCOC2=C1 |
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